Active NAD+ Face Serum Refills, 20ml

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Active NAD+ Face Serum Refills, 20ml

Active NAD+ Face Serum Refills, 20ml

Promotes cellular renewal, stimulates skin’s own collagen production, reduces fine lines and wrinkles

Regular price $270.00
Regular price Sale price $270.00
Sale Sold out
Tax included. Shipping calculated at checkout.
  • 14 days return policy
Formulated with our patent-pending, high-absorption Active NAD+ and pomegranate enzymes, the hero Active NAD+ Face Serum promotes cellular renewal, activates the skin’s own collagen production and reduces fine lines and wrinkles. The light serum also provides intense hydration, promotes homogeneity of skin tone and strengthens the skin’s barrier with its antimicrobial properties.

Key benefits

After 28 days of use:

  • +143% increased homogeneity of complexion
  • +41% increase in radiance
  • +20% increased stimulation of collagen synthesis
  • +21% increased stimulation of elastin synthesis
  • Dry skin reduced by more than 50%
  • Visibly smoother and deeply hydrated skin
  • * based on clinical trials

Scientific results

Purchase plans & refills

How to use

Apply Active NAD+ Face Serum on cleansed face, neck and décolleté morning and evening. Follow with Active NAD+ Essential Cream.

How to store

We recommend refrigerating (not freezing) your Intuisse products to maintain their pure, pharma-grade form. Once opened, our formulations have peak efficacy for two months at room temperature. Spare refills remain stable and potent for up to one year when refrigerated.

Ingredients

  • 5% pharma-grade Intuisse Active NAD+ formulation*
  • Pomegranate enzymes
  • Mediterranean Marine plankton
  • Natural fruit extract
  • Meadowfoam seed oil * due to bio-active ingredients, refrigerate for optimum efficacy for up to one year. Once opened, use within two months.

Cold storage

View full details

Frequently Asked Questions

Intuisse Active NAD+ Face Serum and refill beside the Intuisse skincare fridge. How to refill and why NAD+ is best kept cold.

What is the Active NAD+ Face Serum and how does it benefit the skin?

Our Face Serum is a lightweight yet powerful formula with 5% pharma-grade Active NAD+, Mediterranean marine plankton, pomegranate enzymes, and meadowfoam seed oil, delivered in a patented Swiss liposomal system.

NAD+ is a vital coenzyme found in every cell, essential for energy production, DNA repair, and cellular longevity. As levels naturally decline with age, skin becomes dull, less elastic, and slower to repair.

This serum helps:

  • Recharge skin cells’ energy for better repair and renewal.
  • Improve skin tone, texture, firmness, and elasticity.
  • Enhance barrier strength and hydration.
  • Support collagen, laminin, and elastin production.
  • Promote microcirculation for a natural, healthy glow.

What makes Intuisse NAD+ Face Serum different from other serums on the market?

Most face serums use precursors (like niacinamide) or unstable forms of NAD+ that don’t penetrate the skin barrier effectively. Intuisse stands apart because it features:

  • 5% pharma-grade Active NAD+ – the highest potency available in topical form.
  • Patented liposomal delivery – allows NAD+ to reach the deepest skin layers and be absorbed directly into cells where it’s needed.
  • Clinically backed results – shown to increase collagen, laminin, and elastin in as little as 10–14 days.
  • Complementary actives – pomegranate ferment extract for gentle resurfacing, French marine plankton for antioxidant protection, and meadowfoam seed oil for lightweight hydration.

Together, this makes Intuisse NAD+ Skincare one of the most advanced anti-aging serums available.

At what age should I start using the NAD+ serum for my face?

NAD+ levels begin to decline as early as your 20s, dropping more rapidly in your 30s and 40s. While the serum can benefit skin at any age, starting earlier helps protect cellular energy, prevent premature aging, and maintain firmness over time.

  • 20s–30s:Use preventatively to strengthen skin resilience and delay early signs of aging.
  • 40s+:Use restoratively to help repair visible signs of aging such as fine lines, dullness, and reduced elasticity.

Is the NAD+ Face Serum suitable for all skin types?

Yes – the serum is designed for all skin types, including normal, dry, oily, and combination. It is lightweight, non-comedogenic, and absorbs quickly without residue.

However, since it contains powerful active ingredients, those with very sensitive or highly reactive skin should do a patch test first or consult a dermatologist before use.

How do I use and refill the Intuisse NAD+ Face Serum?

Use: Apply daily in the morning and evening, after cleansing and before moisturizing. Gently massage 2–3 drops into your face, neck, and décolletage. Always follow with SPF in the morning. Optimal results come with consistent use, supporting ongoing skin renewal, improving elasticity, and helping tighten sagging skin over time.

Learn more about creating the best skincare routine for your goals.

Refill:

  1. Twist the top of the applicator (including cap and pump) and remove (& recycle) the empty refill.
  2. Twist the cap of the new refill and attach it to the top applicator pump.
  3. Reattach the bottom applicator bottle by twisting it. Ready to be used again.

Each refill lasts 3–4 weeks. Keep your spare refills in the fridge for freshness and potency.

Can Intuisse's NAD+ Face Serum help with fine lines and wrinkles?

Yes, Intuisse’s Face Serum is clinically formulated to target multiple causes of skin aging. Active NAD+ restores cellular health and DNA repair, boosting collagen, laminin, and elastin for firmer, smoother skin.

Pomegranate ferment extract gently resurfaces dull texture, while Mediterranean marine plankton protects against oxidative stress and improves radiance. Meadowfoam seed oil and squalane deeply hydrate and support barrier repair.

Together, these ingredients reduce the look of fine lines, improve elasticity, and leave skin visibly brighter and smoother.

Visible improvements usually appear within 28 days of consistent AM/PM use.

Can I use the Intuisse NAD+ Face Serum with other active skincare ingredients?

Yes. It layers well with most actives such as hyaluronic acid, vitamin C, and peptides. Avoid using with highly exfoliating acids in the same routine, as this may cause irritation.

For best results:

AM routine: Use with hydrating serums, antioxidants, and SPF.
PM routine: Pair with nourishing creams or peptides for overnight repair. You can explore ourskincare routine guidefor layering tips.

Is the Intuisse NAD+ Face Serum clean & vegan?

The Active NAD+ Face Serum is Vegan, non-GMO, and our formula is 97% naturally derived. It contains a subtle fragrance with no allergens. Packaged sustainably with refillable applicators, recyclable refills, and FSC-certified cartons that are biodegradable and compostable. Learn more about NAD+ Skincare and our clean formulation approach.

Do I need to store the Intuisse NAD+ Face Serum in the fridge?

You don't have to. Our formula is stable at room temperature for over 2 months. We recommend inserting one refill in the applicator and keeping it in your bathroom, while keeping the spare refills chilled for maximum NAD+ potency and extended shelf life (over 2 years). Chilled application also gives a soothing, de-puffing effect and can enhance your skincare routine.

  • 5 stars: 69 (86%)
  • 4 stars: 5 (6%)
  • 3 stars: 2 (3%)
  • 2 stars: 2 (3%)
  • 1 star: 2 (3%)
Some of the reviews shown are from related products the merchant grouped with this one.
E
Erika Cross
Really good product very

Really good product very happy

I
Inga
Best switch I’ve made in a while

I started using the Intuisse face serum two months ago together with the face cream, and I can already see an improvement in my skin’s appearance. It feels rejuvenated and glowing! I also love the texture and how nice it feels on my skin. I’ve researched a lot about the science behind this skincare, and it gives me confidence to use it long term. The refill system strongly aligns with my values too.

a
aurora d.
Neck and décolleté

Since 10 days twice a day I decided to use the serum especially on my neck and décolleté (49 year’s old) and I feel day after day more tightening 🤗 for sure I continue the routine 😊

K
Kayode Ariyo
Best skin products ever

I’ve tried countless skincare brands over the years, but Intuisse genuinely stands out as a game-changer. From the moment I started using their products, I noticed a visible difference in the texture, tone, and overall health of my skin.

What sets Intuisse apart is not just the sleek, high-end packaging, but the results.

M
Maria Pierfederici
A lovely surprise

I take care of my skin and i like trying new serums and creams but “intuisse” really surprise me.
I have been using the serum and the cream for few months and my skin looks very hydrated and more radiant than usual, overall super happy.

B
Brianna Mellon
Best!!!

Completely changed the texture of skin within a couple weeks. Can’t live without these products now!

B
Barbara Mendoza
Postive difference

I’m seeing a difference in my face and neck/decolletage skin. My adult daughter has commented. I’m 73, and an Esthetician was actually shocked! Im on my 2nd order of the face and cream with NAD+.

J
JODY POST

Very small, took awhile for pump to work. Only sm amount comes out for an $ item.

S
Sarah Stein
Noticeable Improvement

Light yet deeply hydrating. My skin's improvement was immediately noticeable. Amazing since my skin is very dry yet also acne prone.

J
Jacqueline Tobin
Best hydrating serum

I have been using this serum every night for the past few months and my skin is very hydrated. I see a difference in the radiance of my skin as well. Good to also use on your neck and chest area.

S
Sarina
Once I bought an eye cream

I bought an eye cream just once. But they are sending again their products without placing any order
I was trying to reach them with NO SUCCESS
Still using my credit card and sending their products

D
Diane

Game changer in face serums, and cleansers. I am an avid seeker of the best facial products in this one surpasses expectations.

M
MEGAN Wendling
Love it

Believe it or not I noticed a difference after the 1st day I used the product! My only complaint is the size of the tube for the price!

B
Becky Griffith
Fabulous product

I love the way it feels on my skin. Will give a heads up after two weeks.

L
Lisa Russell
Don’t know

I did not receive the eye serum that I ordered. Still have not heard back from customer service. So far, not good.

N
Natasha conde
Good- Has Parfum/fragrance

The products seem promising, and I appreciate the science behind their development. However, I believe that products of this caliber and price should not contain parfum/fragrance. With the current research showing that fragrance ingredients don’t have to be fully disclosed, combined with the potential for irritation and other health issues, it feels like an unwise choice, to include in the products- which has left me disappointed. As someone who is committed to biohacking skincare and reducing toxic exposure, I’ve decided not to continue purchasing these products due to this concern.
(Even if the parfums are “essential
Oils” it is unknown how and where the oils are sourced from which makes it an unreliable source)

K
Kathryn Bailey

Great product

S
SUSAN TRAUMAN

This the very very best!!!!

K
Karissa Sosnoski

Made my skin look noticeably better after I finished my first bottle. Especially the skin around my lips.

S
S.H.

Really tightened and cleared up my skin very quickly just a shame you don’t get much product for the money

T
Travis

It has an overwhelming smell of perfume.

M
Michelle

Sadly costs way too much for too little product. No noticeable lasting effect and is drying my skin out.

S
Savannah Todd
The best thing for my skin!!

I absolutely fell in love with this product and my skin has never looked better.

A
Astrid Nellemann
Great for sensitive skin and rosacea!

I have always had super sensitive skin and have in addition been suffering from rosacea for the past 2 years. Am always on the look out for good skincare products to help alleviate the symptoms and therefore starting using the Intuisse cream and serum (from starter pack) 2 months ago. Both the cream and serum are absolutely brilliant. It took a week or so to properly settle into my skin, but from then onwards has simply been the best. I don't have any redness anymore. In addition the eye masks which came along with the starter pack are very very good also. Can only give the products my warmest recommendation - as an additional plus, finally a skincare branding that is thinking about sustainability/minimizing its packaging footprint - definitely 5 stars!

V
Vanessa
AMAZING GLOW

I've been using the Serum with the Essential Cream and just LOVE how I wake up with glowing skin. My skin feels hydrated throughout the day (I tap once in a while to actually feel it) and I feel I can get away without wearing foundation. Easy to apply, nice smell and super results.

L
Lydie Dumasy
Excellent Produit

J'utilise ce serum depuis 3 semaines jour et nuit et je sens ma peau plus douce, hydratée et lumineuse.
Suis vraiment conquise par ce produit et le recommende grandement. Ai hate de le trouver sur notre marché français.
Lydie Dumasy

D
Doria
The perfect serum

This serum has replaced all other evening serums in my skincare routine. I still use some others in the morning, but this has become my go to in the evenings. It feels like silk on the skin and is super smoothing and after using for two weeks, I have already noticed an improvement in skin texture as well as the reduction of some fine lines around my mouth. Very impressed!!

T
Taryn Tavella
My skin is glowing!

This serum works wonders It has replaced all other serums in my routine it does not dry out my skin and makes me feel fresh and glowing. I also love that the packaging is sustainable too!

S
Sanda
A must have!

My skin looks so good! The serum really helped it to feel and look brighter, like silk on my skin.
The smell is absolutely divine and its texture is light.
The serum became part of my daily routine. It is the best product on the market, it cannot be beaten! Works on wrinkles and fine lines fantastically-a must have.

Z
Zrinka Smodlaka
I love this product

I’ve been using Intuisse serum for about a month and my skin is visibly so much smoother and tighter. Have a problem with dark spots which are lighter and less noticeable since I’ve been using serum. I love the product. Texture is so gentle and mild smell that stays with you.

Z
Zi
I love this product

I’ve been using Intuisse serum for a month now and my skin is visibly smoother and brighter. Have problems with dark spots that have become lighter and less visible since using it. I love this product. Nice texture and mild smell that follows you around after use.

Z
Zrinka
Excellent product

I love this face serum. I’ve been using it day and night for over a week and my skin already feels smoother, more hydrated and much healthier and radiant.
Definitely worth trying

  • 5 stars: 69 (86%)
  • 4 stars: 5 (6%)
  • 3 stars: 2 (3%)
  • 2 stars: 2 (3%)
  • 1 star: 2 (3%)
Some of the reviews shown are from related products the merchant grouped with this one.
E
Erika Cross
Really good product very

Really good product very happy

I
Inga
Best switch I’ve made in a while

I started using the Intuisse face serum two months ago together with the face cream, and I can already see an improvement in my skin’s appearance. It feels rejuvenated and glowing! I also love the texture and how nice it feels on my skin. I’ve researched a lot about the science behind this skincare, and it gives me confidence to use it long term. The refill system strongly aligns with my values too.

a
aurora d.
Neck and décolleté

Since 10 days twice a day I decided to use the serum especially on my neck and décolleté (49 year’s old) and I feel day after day more tightening 🤗 for sure I continue the routine 😊

K
Kayode Ariyo
Best skin products ever

I’ve tried countless skincare brands over the years, but Intuisse genuinely stands out as a game-changer. From the moment I started using their products, I noticed a visible difference in the texture, tone, and overall health of my skin.

What sets Intuisse apart is not just the sleek, high-end packaging, but the results.

M
Maria Pierfederici
A lovely surprise

I take care of my skin and i like trying new serums and creams but “intuisse” really surprise me.
I have been using the serum and the cream for few months and my skin looks very hydrated and more radiant than usual, overall super happy.

B
Brianna Mellon
Best!!!

Completely changed the texture of skin within a couple weeks. Can’t live without these products now!

B
Barbara Mendoza
Postive difference

I’m seeing a difference in my face and neck/decolletage skin. My adult daughter has commented. I’m 73, and an Esthetician was actually shocked! Im on my 2nd order of the face and cream with NAD+.

J
JODY POST

Very small, took awhile for pump to work. Only sm amount comes out for an $ item.

S
Sarah Stein
Noticeable Improvement

Light yet deeply hydrating. My skin's improvement was immediately noticeable. Amazing since my skin is very dry yet also acne prone.

J
Jacqueline Tobin
Best hydrating serum

I have been using this serum every night for the past few months and my skin is very hydrated. I see a difference in the radiance of my skin as well. Good to also use on your neck and chest area.

S
Sarina
Once I bought an eye cream

I bought an eye cream just once. But they are sending again their products without placing any order
I was trying to reach them with NO SUCCESS
Still using my credit card and sending their products

D
Diane

Game changer in face serums, and cleansers. I am an avid seeker of the best facial products in this one surpasses expectations.

M
MEGAN Wendling
Love it

Believe it or not I noticed a difference after the 1st day I used the product! My only complaint is the size of the tube for the price!

B
Becky Griffith
Fabulous product

I love the way it feels on my skin. Will give a heads up after two weeks.

L
Lisa Russell
Don’t know

I did not receive the eye serum that I ordered. Still have not heard back from customer service. So far, not good.

N
Natasha conde
Good- Has Parfum/fragrance

The products seem promising, and I appreciate the science behind their development. However, I believe that products of this caliber and price should not contain parfum/fragrance. With the current research showing that fragrance ingredients don’t have to be fully disclosed, combined with the potential for irritation and other health issues, it feels like an unwise choice, to include in the products- which has left me disappointed. As someone who is committed to biohacking skincare and reducing toxic exposure, I’ve decided not to continue purchasing these products due to this concern.
(Even if the parfums are “essential
Oils” it is unknown how and where the oils are sourced from which makes it an unreliable source)

K
Kathryn Bailey

Great product

S
SUSAN TRAUMAN

This the very very best!!!!

K
Karissa Sosnoski

Made my skin look noticeably better after I finished my first bottle. Especially the skin around my lips.

S
S.H.

Really tightened and cleared up my skin very quickly just a shame you don’t get much product for the money

T
Travis

It has an overwhelming smell of perfume.

M
Michelle

Sadly costs way too much for too little product. No noticeable lasting effect and is drying my skin out.

S
Savannah Todd
The best thing for my skin!!

I absolutely fell in love with this product and my skin has never looked better.

A
Astrid Nellemann
Great for sensitive skin and rosacea!

I have always had super sensitive skin and have in addition been suffering from rosacea for the past 2 years. Am always on the look out for good skincare products to help alleviate the symptoms and therefore starting using the Intuisse cream and serum (from starter pack) 2 months ago. Both the cream and serum are absolutely brilliant. It took a week or so to properly settle into my skin, but from then onwards has simply been the best. I don't have any redness anymore. In addition the eye masks which came along with the starter pack are very very good also. Can only give the products my warmest recommendation - as an additional plus, finally a skincare branding that is thinking about sustainability/minimizing its packaging footprint - definitely 5 stars!

V
Vanessa
AMAZING GLOW

I've been using the Serum with the Essential Cream and just LOVE how I wake up with glowing skin. My skin feels hydrated throughout the day (I tap once in a while to actually feel it) and I feel I can get away without wearing foundation. Easy to apply, nice smell and super results.

L
Lydie Dumasy
Excellent Produit

J'utilise ce serum depuis 3 semaines jour et nuit et je sens ma peau plus douce, hydratée et lumineuse.
Suis vraiment conquise par ce produit et le recommende grandement. Ai hate de le trouver sur notre marché français.
Lydie Dumasy

D
Doria
The perfect serum

This serum has replaced all other evening serums in my skincare routine. I still use some others in the morning, but this has become my go to in the evenings. It feels like silk on the skin and is super smoothing and after using for two weeks, I have already noticed an improvement in skin texture as well as the reduction of some fine lines around my mouth. Very impressed!!

T
Taryn Tavella
My skin is glowing!

This serum works wonders It has replaced all other serums in my routine it does not dry out my skin and makes me feel fresh and glowing. I also love that the packaging is sustainable too!

S
Sanda
A must have!

My skin looks so good! The serum really helped it to feel and look brighter, like silk on my skin.
The smell is absolutely divine and its texture is light.
The serum became part of my daily routine. It is the best product on the market, it cannot be beaten! Works on wrinkles and fine lines fantastically-a must have.

Z
Zrinka Smodlaka
I love this product

I’ve been using Intuisse serum for about a month and my skin is visibly so much smoother and tighter. Have a problem with dark spots which are lighter and less noticeable since I’ve been using serum. I love the product. Texture is so gentle and mild smell that stays with you.

Z
Zi
I love this product

I’ve been using Intuisse serum for a month now and my skin is visibly smoother and brighter. Have problems with dark spots that have become lighter and less visible since using it. I love this product. Nice texture and mild smell that follows you around after use.

Z
Zrinka
Excellent product

I love this face serum. I’ve been using it day and night for over a week and my skin already feels smoother, more hydrated and much healthier and radiant.
Definitely worth trying