Intuisse Anti-Aging Skincare with NAD+ for Mature and Aging Skin

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in every living cell in our bodies. It plays an essential role in celullar energy production, DNA repair, managing cell death and longevity and to keep our cells functioning at their best.

- NAD+ drives energy production in the mitochondria - the cells 'powerhouse' - by converting nutriets from food into energy. It does this by helping to shift the energy produced in the Krebs Cycle into molecules of ATP (usable energy), ensuring cells have the fuel they need to perform.

- It also supports DNA repair enzymes such as PARPs, which help preserve genomic stability, and activates sirtuins, which are involved in stress responses, inflammation control, and epigenetic regulation.

By maintaining healthy NAD⁺ levels, these critical cellular processes can continue working efficiently, which contributes to resilience, repair, and overall healthy aging.

NAD+ levels decline naturally as we get older due to several interconnected processes in the body. Why?

- Higher consumption: NAD+-using enzymes increase in activity with age and inflammation, which means that more NAD+ is consumed on a daily basis while our body' ability to create new NAD+ also slows down.

- Lower recycling: At the same time, the body’s ability to recycle and restore NAD+ through the salvage pathway becomes less efficient with age.

- More DNA & oxidative stress: In addition, older cells are exposed to greater levels of oxidative and DNA damage, which activates NAD+-consuming repair enzymes even further.

Together, these factors create an imbalance where more NAD+ is being used up and less is being renewed, leading to an overall decline in NAD⁺ levels with age.

As we age, NAD+ levels in the skin naturally decline, leading to visible signs of aging such as wrinkles, loss of firmness, and uneven tone.

NAD+ levels can start declining as early as in our 20s, dropping sharper in your 30s/40s, and declining by more than 50% by the time we reach 50.

Intuisse's NAD+ skincare helps replenishes these levels directly within skin cells, boosting their ability to renew, repairs and defect against damage. For mature skin, this means better elasticity, reduction of fine lines and wrinkles, improved texture and radiance, and long-term resilience.

The most effective products for aging skin go beyond surface hydration and work at the cellular level to restore energy, repair damage, and rebuild firmness.

At Intuisse, two stand out:

Active NAD⁺ Face Serum: Powered by 5% pharma-grade NAD+, pomegranate enzymes, mediterranean marine plankton, meadowfoam seed oil, and fruit extracts. This combination stimulates cellular renewal, brightens uneven tone, protects against oxidative stress, and strengthens the skin barrier, leaving skin smoother, clearer, and more resilient.

Essential Cream: A deeply hydrating, restorative cream with Active NAD+, olive-derived squalane, natural peptides, and antioxidants. Together, they replenish moisture, support collagen and elastin, calm inflammation, and protect against pollution, improving firmness, elasticity, and radiance over time.

These products are designed to work synergistically, giving skin the energy, hydration, and protection it needs to look healthier and younger at every age.

Yes. NAD+ skincare products support skin’s natural cell repair mechanisms and help minimize oxidative stress that contributes to discoloration. When combined with peptides and hydrating ingredients, NAD+ products can help soften the appearance of brown spots, even out skin tone and brighen skin.

Intuisse formulas are created to be safe and effective for all skin types. They are designed to work with your body's natural renewal functions, making them effective yet gentle.

However, because our products use powerful active ingredients that are highly potent, we recommend performing a patch test first if your skin is very sensitive or prone to reactions. For best guidance, consult with your dermatologist before use.

All Intuisse products are non-GMO and formulated with the highest clean-beauty standards of quality and safety.

- Our entire line is vegan, with the exception of the Active NAD+ Eye Mask, which contains native collagen for its skin-firming benefits.

- Our formulas are up to 97% naturally derived, with carefully selected biotech actives that go beyond what nature can do on its own.

- Our eye care products are completely fragrance-free, while our face products include a light, non-allergenic fragrance to enhance the experience without irritating the skin.

We’re committed to transparency and safety: no parabens, no sulfates, and no unnecessary fillers, just clinically proven actives that deliver results.

General rule: apply from thinnest to thickest textures, letting each layer absorb.

AM/PM: Start with a freshly cleansed face, neck, and décolleté.

1. Active NAD+ Cleansing Lotion – Sweep over dry skin to cleanse/refresh (it doubles as a prebiotic toner and gentle makeup remover).

2. Active NAD+ Face Serum – Apply 2 pumps over face and neck.

3. Active NAD+ Eye Serum – Use one pump tapped around the eye area.
Active NAD+ Essential Cream – Apply 2 pumps to the face and neck to seal in hydration.

4. Broad-spectrum SPF 30+ – Essential daily.

Active NAD⁺ Eye Mask – Use whenever needed for 15 minutes, then follow with Eye Serum.

Skincare works in sync with your skin’s natural renewal cycle, which typically takes up to 28 days for complete turnover. That means lasting, visible results build over several weeks with with consistent AM/PM use.

Immediately/first few uses: Noticeable improvements in hydration, radiance and skin comfort.

10-14 days: Clinical studies show increased stimulation of collagen, laminin, and elastin, helping skin feel firmer and more resilient.

28 days: Visible improvements in texture, fine lines, and firmness as full skin cell turnover is achieved.

8–12 weeks: Results continue to strengthen, with enhanced elasticity, resilience, and a visibly healthier complexion.

Individual results vary based on skin type, routine consistency, lifestyle and sun protection.

We are committed to sustainable science - that means caring for both your skin and the planet.

Our packaging is thoughtfully designed with a refill system to minimize waste. Each product comes with a reusable applicator and recyclable refills:

- Refills: The inner refills can be recycled.

- Reusable applicators: Keep the sleek applicators as they’re built for long-term use with can be reused with fresh refills.

- Eco-friendly packaging: All outer cartons and protective packaging are FSC-certified, biodegradable, and compostable, ensuring a lighter footprint.

By choosing Intuisse, you’re not only investing in advanced skincare, you’re also supporting a cleaner, more sustainable future.

You do not have to store your products in the fridge, however, we do recommend keeping your Intuisse products chilled because it keeps our powerful actives at peak efficiency and elevates your skincare ritual.

Better Instant Performance: Applying cold serums and creams has an immediate de-puffing and soothing effect, particularly around the delicate eye area.

Enhanced Potency & Shelf life: NAD+ is highly unstable at different tempertatures which is why our we have created a formula that keeps it stable at room tempertature for over 2 months. However, keeping it cool slows down the degradation of NAD+, keeping your products fresher for longer. Refrigirating our products preserves the stability and effectiveness of NAD+ as well as other ingredientsfor over 2 years, ensuring they deliver their full benefits with every use.

We realise that storing skincare in the fridge can feel like a hassle. That’s why we created a refill system. Each refills lasts 3-4 weeks, so pop one in your applicator and use it normally in your bathroom - it should run out before there is any effect on the potency of NAD+. Keep you spare refills and Eye Masks chilled until you are ready to use them.

For those who want to elevate their skincare ritual, we designed the Intuisse Fridge Kit (available for US customers). This compact beauty fridge is tailored to keep your products at the ideal temperature, making sure your skincare stays fresh and feels amazing.

Some of the most well-known anti-aging ingredients in skincare include peptides, collagen, retinol, vitamin C, hyaluronic acid, and exosomes. Each plays a valuable role:

Peptides: Signal the skin to produce more collagen and elastin, improving firmness and smoothness. We include them in our Essential Cream.

Collagen: Provides structure and plumpness to skin. Our Eye Masks contain native collagen and the core of our whole product line is Active NAD+, which stimulates your skin’s natural collagen production.

Retinol: Speeds up cell turnover and targets fine lines, though it can sometimes cause irritation. At 5%, Active NAD+ acts as an alternative to retinol. Our forumla stimulates collagen, laminin and elastin to the same extent as retinol withouth any of the side effects.

Vitamin C: Brightens skin and provides antioxidant protection. While none of our products include vitmain C, they do inlcude antioxidants and enzymes provide similar skin support and brightening effects.

Hyaluronic Acid: Deeply hydrates, plumping the skin and reducing dryness. Our Active NAD+ Eye Serum contains a combination of 4 types of hyaluronic acids.

Exosomes: Emerging actives that support cellular communication and repair. NAD+ complements this process by fueling the cellular energy exosomes rely on to deliver their regenerative signals effectively, making the two highly synergistic.

What makes NAD+ unique is that it works at the cellular energy level, fueling repair, DNA protection, and collagen stimulation, making it the foundation of long-term skin health. Our Intuisse regimen combines NAD+ with peptides, collagen, and other proven actives for a complete, science-backed approach to anti-aging.